PUBLICATIONS
Articles
2020
Lahiguera Á, Hyroššová P, Figueras A, Garzón D, Moreno R, Soto-Cerrato V, McNeish I, Serra V, Lazaro C, Barretina P, Brunet J, Menéndez J, Matias-Guiu X, Vidal A, Villanueva A, Taylor-Harding B, Tanaka H, Orsulic S, Junza A, Yanes O, Muñoz-Pinedo C, Palomero L, Pujana MÀ, Perales JC, Viñals F. “Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors”. EMBO Molecular Medicine 12 (6): e11217, 2020.
Medina-Jover F, Gendrau-Sanclemente N, Viñals F. “SGK1 is a signalling hub that controls protein synthesis and proliferation in endothelial cells”. FEBS Letters 594 (19): 3200-3215, 2020.
2019
Iriarte A, Figueras A, Cerdà P, Mora JM, Jucglà A, Penín R, Viñals F, Riera-Mestre A. “PI3K (Phosphatidylinositol 3-Kinase) Activation and Endothelial Cell Proliferation in Patients with Hemorrhagic Hereditary Telangiectasia Type 1”. Cells 8: E971, 2019.
2018
Figueras A, Alsina-Sanchís E, Lahiguera A, Abreu M, Muinelo-Romay L, Moreno-Bueno G, Casanovas O, Graupera M, Matias-Guiu X, Vidal A, Villanueva & Viñals F. “A role for CXCR4 in peritoneal and hematogenous ovarian cancer dissemination”. Molecular Cancer Therapeutics 17: 532-543, 2018.
Alsina-Sanchís E, García-Ibáñez Y, Figueiredo AM, Riera-Domingo C, Figueras A, Matias-Guiu X, Casanovas O, Botella LM, Pujana MA, Riera-Mestre A, Graupera M & Viñals F. “ALK1 (Activin-Receptor Like Kinase 1) Loss Results in Vascular Hyperplasia in Mice and Humans Through PI3K (Phosphatidylinositol 3-Kinase) Activation”. Arteriosclerosis Thrombosis and Vascular Biology: 38(5): 1216-1229, 2018.
2017
E Alsina-Sanchís, A. Figueras, A. Lahiguera, M. Gil-Martín, B Pardo, JM Piulats, L. Martí, J. Ponce, X. Matias-Guiu ,A Vidal, A Villanueva & Viñals F. “TGFβ Controls Ovarian Cancer Cell Proliferation”. International Journal Molecular Science 18: E1658, 2017.
2016
E Alsina-Sanchís, A. Figueras, A. Lahiguera, A Vidal, O Casanovas, M Graupera, A Villanueva & Viñals F. “The TGFβ pathway stimulates ovarian cancer cell proliferation by increasing IGF1R levels.” International Journal of Cancer: 139: 1894-1903, 2016.
2014
M. Juliachs, C. Muñoz, C.A. Moutinho, A. Vidal, E. Condom, M. Esteller, M. Graupera, O. Casanovas, J.R. Germà, A. Villanueva & F. Viñals. “The PDGFRbeta-AKT Pathway Contributes To CDDP-Acquired Resistance In Testicular Germ Cell Tumors” Clinical Cancer Research: 658-667, 2014.
2013
Juliachs M, Vidal A, Del Muro XG, Piulats JM, Condom E, Casanovas O, Graupera M, Germà JR, Villanueva A, Viñals F. “Effectivity of pazopanib treatment in orthotopic models of human testicular germ cell tumors.” BMC-Cancer 13: 382, 2013.
Juliachs M, Castillo-Ávila W, Vidal A, Piulats JM, Garcia Del Muro X, Condom E, Hernández-Losa J, Teixidó C, Pandiella A, Graupera M, Casanovas O, Germà JR, Villanueva A, Viñals F. “ErbBs inhibition by lapatinib blocks tumor growth in an orthotopic model of human testicular germ cell tumor” International Journal of Cancer 133: 235-246, 2013.
A. Figueras, M.A. Arbós, M.T. Quiles, F. Viñals, J.R. Germà, & Capellà G. “The impact of KRAS mutations on VEGF-A production and tumour vascular network”. BMC-Cancer 13: 125, 2013.
Vives M, Ginestà MM, Gracova K, Graupera M, Casanovas O, Capellà G, Serrano T, Laquente B & Viñals F. “Metronomic chemotherapy following the maximum tolerated dose is an effective anti-tumour therapy affecting angiogenesis, tumour dissemination and cancer stem cells.” International Journal of Cancer 133: 2464-2472, 2013.
2010
B. del Valle-Pérez, V.G. Martínez, C. Lacasa-Salavert, A. Figueras, S.S. Shapiro, T. Takafuta, O. Casanovas, G. Capellà, .F. Ventura & F. Viñals. “Filamin B plays a key role in VEGF-induced endothelial cell motility through its interaction with Rac-1 and Vav-2” Journal of Biological Chemistry 285: 10748-10760, 2010.
2009
W. Castillo-Ávila, J.M. Piulats, X. Garcia del Muro, A. Vidal, E. Condom, O. Casanovas, J. Mora, J.R. Germà, G. Capellà, A. Villanueva & F. Viñals. “Sunitinib inhibits tumor growth and synergizes with cisplatin in orthotopic models of cisplatin-sensitive and resistant human testicular germ cell tumors” Clinical Cancer Researcch 15: 3384-3395, 2009.
Collaborations
Hyrossova P, Arago M, Moreno-Felici J, Fu X, Garcia-Roves P, Burgess S, Mendez-Lucas A, Figueras A, Viñals F & Perales JC. “PEPCK-M Recoups Tumor Cell Anabolic Potential in a PKC-ζ Dependent Manner”. Cancer & Metabolism 9(1): 1, 2021.
Bernat-Peguera A, Navarro-Ventura J, Lorenzo-Sanz L, da Silva-Diz V, Bosio M, Palomero L, Penin R, Pérez Sidelnikova D, Bermejo Segú JO, Taberna M, Vilariño N, Piulats JM, Mesia R, Viñals JM, González-Suárez E, Capella-Gutierrez S, Villanueva A, Viñals F & and Muñoz P. “FGFR inhibition overcomes resistance to EGFR-targeted therapy in epithelial-like cutaneous carcinoma”. Clinical Cancer Research 27(5): 1491-1504, 2021.
García-Cano J, Sánchez-Tena S, Sala-Gaston J, Figueras A, Viñals F, Bartrons R, Ventura F, Rosa JL. “Regulation of the MDM2-p53 pathway by the ubiquitin ligase HERC2”. Molecular Oncology 14(1): 69-86, 2020.
Aragó M, Moreno-Felici J, Abás S, Rodríguez-Arévalo S, Hyroššová P, Figueras A, Viñals F, Pérez B, Loza MI, Brea J, Latorre P, Carrodeguas JA, García-Rovés PM, Galdeano C, Ginex T, Luque FJ, Escolano C, Perales JC. “Pharmacology and preclinical validation of a novel anticancer compound targeting PEPCK-M”. Biomed Pharmacother. 121: 109601, 2020.
Bernat-Peguera A, Simón-Extremera P, da Silva-Diz V, López de Munain M, Díaz-Gil L, Penin RM, González-Suárez E, Pérez Sidelnikova D, Bermejo O, Viñals JM, Viñals F, Muñoz P. “PDGFR-induced autocrine SDF-1 signaling in cancer cells promotes metastasis in advanced skin carcinoma”. Oncogene 38: 5021-5037, 2019.
Piulats JM, Vidal A, García-Rodríguez FJ, Muñoz C, Nadal M, Moutinho C, Martínez-Iniesta M, Mora J, Figueras A, Guinó E, Padullés L, Aytés À, Mollevi DG, Puertas S, Martínez-Fernández C, Castillo W, Juliachs M, Moreno V, Muñoz P, Stefanovic M, Pujana MA, Condom E, Esteller M, Germà-LLuch JR, Capella G, Farré L, Morales A, Viñals F, Garcia Del Muro X, Cerón J, Villanueva A. “Orthoxenografts of testicular germ cell tumors demonstrate genomic changes associated with cisplatin resistance and identify PDMP as a re-sensitizing agent”. Clinical Cancer Research 24(15): 3755-3766, 2018.
Angulo-Urarte A, Casado P, Castillo SD, Kobialka P, Kotini MP, Figueiredo AM, Castel P, Rajeeve V, Milà-Guasch M, Millan J, Wiesner C, Serra H, Muixi L, Casanovas O, Viñals F, Affolter M, Gerhardt H, Huveneers S, Belting HG, Cutillas PR, Graupera M. “Endothelial cell rearrangements during vascular patterning require PI3-kinase-mediated inhibition of actomyosin contractility”. Nature Communications 16: 4826, 2018.
da Silva-Diz V, Simón-Extremera P, Bernat-Peguera A, de Sostoa J, Urpí M, Penin RM, Pérez Sidelnikova D, Bermejo O, Viñals JM, Rodolosse A, Gonzalez-Suarez E, Gómez Moruno A, Pujana MA, Esteller M, Villanueva A, Viñals F, Muñoz P. “Cancer stem-like cells act at via distinct signaling pathways in promoting late stages of malignant progression.” Cancer Research 76:1245-1259, 2016.
Jiménez‐Valerio G, Martínez‐Lozano M, Bassani N, Vidal A, Ochoa‐de‐Olza M, Suárez C, García‐del‐Muro X, Carles J, Viñals F, Graupera M, Indraccolo S & Casanovas O. “Resistance to Antiangiogenic Therapies by Metabolic Symbiosis in Renal Cell Carcinoma PDX Models and Patients” Cell Reports 15: 1134-1143, 2016.
R. Ola, A. Dubrac, J. Han, F. Zhang, J.S. Fang, B. Larrivée, M. Lee, A.A. Urarte, J.R. Kraehling, G. Genet, K.K. Hirschi, W.C. Sessa, F. Viñals Canals, M. Graupera, M. Yan, L.H. Young, P.S. Oh & A. Eichmann. “PI3 kinase inhibition improves vascular malformations in mouse models of hereditary haemorrhagic telangiectasia” Nature Communications 7: 13650, 2016.
Serra H, Chivite I, Angulo-Urarte A, Soler A, Sutherland JD, Arruabarrena-Aristorena A, Ragab A, Lim R, Malumbres M, Fruttiger M, Potente M, Serrano M, Fabra À, Viñals F, Casanovas O, Pandolfi PP, Bigas A, Carracedo A, Gerhardt H, Graupera M. ”PTEN mediates Notch-dependent stalk cell arrest in angiogenesis.” Nature Communications 6: 7935, 2015.
P. Lopez-Serra, M. Marcilla, A. Villanueva, A. Ramos-Fernandez, A. Palau, L. Leal-Esteban, J. Wahi, F. Setien-Baranda, K. Szczesna, C. Moutinho, A. Martinez-Cardus, H. Heyn, J. Sandoval, S. Puertas, A. Vidal, X. Sanjuan, E. Martinez-Balibrea, F. Viñals, J.C. Perales, J. Bramsen, T. Ørntoft, C.L Andersen, J. Tabernero, U. McDermott, M. Boxer, M. Vander Heiden, J. Pablo Albar, and M. Esteller. “A DERL3 Associated Defect in the Degradation of SLC2A1 Mediates the Warburg Effect” Nature Communications 5: 3608, 2014.
Méndez-Lucas A, Hyroššová P, Novellasdemunt L, Viñals F, Perales JC. “Mitochondrial Phosphoenolpyruvate Carboxykinase (PEPCK-M) Is a Pro-survival, Endoplasmic Reticulum (ER) Stress Response Gene Involved in Tumor Cell Adaptation to Nutrient Availability”. Journal of Biological Chemistry 289: 22090-22102, 2014.
Cepeda D, Ng HF, Sharifi HR, Mahmoudi S, Cerrato VS, Fredlund E, Magnusson K, Nilsson H, Malyukova A, Rantala J, Klevebring D, Viñals F, Bhaskaran N, Zakaria SM, Rahmanto AS, Grotegut S, Nielsen ML, Szigyarto CA, Sun D, Lerner M, Navani S, Widschwendter M, Uhlén M, Jirström K, Pontén F, Wohlschlegel J, Grandér D, Spruck C, Larsson LG, Sangfelt O. ”CDK-mediated activation of the SCFFBXO28 ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer.” EMBO Molecular Medicine 5: 999-1018, 2013.
A. Soler, H. Serra, W. Pearce, A. Angulo, J. Guillermet-Guibert, L. Friedman, F. Viñals, H. Gerhardt, O. Casanovas, M. Graupera & B. Vanhaesebroeck. “Inhibition of the p110 isoform of PI3 kinase stimulates non-functional tumor angiogenesis.” Journal of Experimental Medicine 210: 1937-1945, 2013.