Understanding how these mechanisms of signal transduction work can explain how biological processes are controlled in a normal physiological context, but also, the alterations that take place in many pathologies.
Our group investigates the role of different signaling pathways in physiological processes, as members of the families of TGFbeta and EGFR control angiogenesis, or the role of different ubiquitin ligases regulating the function of signal proteins.
Molecular signaling in Cancer
Our research focus
The molecular signaling cascades that take place inside the cells are essential to respond to changes in their environment or to alter their homeostasis, for example, at the level of cell proliferation, movement, growth or metabolism.
Latest publications
Tumors defective in homologous recombination rely on oxidative metabolism: relevance to treatments with PARP inhibitors.
Lahiguera Á, Hyroššová P, Figueras A, Garzón D, Moreno R, Soto-Cerrato V, McNeish I, Serra V, Lazaro C, Barretina P, Brunet J, Menéndez J, Matias-Guiu X, Vidal A, Villanueva A, Taylor-Harding B, Tanaka H, Orsulic S, Junza A, Yanes O, Muñoz-Pinedo C, Palomero L, Pujana MÀ, Perales JC, Viñals F.
EMBO Molecular Medicine 12 (6): e11217, 2020.
SGK1 is a signalling hub that controls protein synthesis and proliferation in endothelial cells
Ferran Medina-Jover, Núria Gendrau-Sanclemente, Francesc Viñals
FEBS Lett. 2020 Oct;594(19):3200-3215.
CONTACT US
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ADDRESS
Dr. Francesc Viñals Canals
Program Against Cancer Therapeutic Resistance, ProCURE
Catalan Institute of Oncology
Bellvitge Biomedical Research Institute, IDIBELL
3 floor, LRT1, Hospital Duran i Reynals
Gran Via 199-203, 08907 L’Hospitalet de Llobregat